CD09 Acrylate co-polymers: no cause for concern

Abstract Acrylate co-polymers are frequently used ingredients, believed to have low allergenic potential, present in a wide range of cosmetics, including skincare products, hairspray and nail varnish. Concerns been expressed that individuals who sensitized (meth)acrylate monomers ultraviolet (UV)-cured products may suffer elicitation reactions due subsequent exposure residual monomer impurities acrylate co-polymers. The British Society for Cutaneous Allergy (BSCA) the Cosmetic, Toiletry Perfumery Association collaborated investigate potential BSCA prospectively audited data between 1 September 2021 2022 from clinical databases 20 patch test centres UK Ireland, assessing frequency sensitization three Patients with suspected or known allergy (meth)acrylates facial dermatitis (in some units) consecutive patients were tested glyceryl acrylate/acrylic acid co-polymer 10% aqueous (aq.) (Lubrajel PF; United Guardian, Hauppauge, NY, USA), sodium polyacrylate 2% aq. (Cosmedia SP; BASF, Ludwigshafen, Germany) EDT acrylates/C10-30 alkyl cross-polymer (Carbopol® ETD 2020 polymer; Lubrizol Advanced Materials, Wickliffe, OH, USA). During their manufacture, pH preparations was adjusted within 5.5–6.5. antimicrobial preservative preparations, phenoxyethanol 1% (Chemotechnique, Vellinge, Sweden), also tested. Readings carried out on days 2 4. positive (1+/2+/3+), irritant doubtful recorded. In total, 1302 Of these, 335 addition series, 423 series 277 267 consecutively baseline series. To co-polymer, there one reaction patient allergic multiple reaction. polyacrylate, four reactions, 1+ reaction; all cases, relevance unknown no demonstrable allergy. There cross-polymer. phenoxyethanol. any (n = 67), co-polymer. Sensitization these concentrations is rare. It not possible attribute (meth)acrylate-sensitized cosmetic ingredient an International Nomenclature Cosmetic Ingredient name containing ‘acrylate co-polymer’.